The new coronavirus particularly likes mucosal epithelial cells rich in angiotensin-converting enzyme 2 receptors, such as mouth, nose, respiratory tract, conjunctiva, etc. After the new coronavirus combines with the receptors on the cell surface, it penetrates the cell membrane into the cell and continuously replicates to produce A large number of next-generation viruses are then released outside the cells, invading surrounding cells or being excreted through sputum for transmission. After entering the lungs through the respiratory tract, the new coronavirus multiplies rapidly in bronchial and alveolar epithelial cells, causing tissue congestion and edema, while the body mobilizes lymphocytes and monocytes to defend itself. The result is thickened interstitial lungs and alveoli Intraluminal exudation increases to form a transparent membrane-like structure. In severe cases, gas exchange capacity is affected. Therefore, clinical manifestations include fever, cough, wheezing, severe patients with dyspnea, shock, coma, multiple organ failure, and life-threatening.
It’s because of such pathological changes in the body after the virus infection that the chest CT will appear corresponding image.
Pic 1 is mild, only two small shadows appear in the lower left lung, showing a faint, focal, ground-glass density effect
Pic 2 If the condition becomes worse, the range of lesions will expand, and both lungs may develop, but the lesions are mainly located in the middle and outer bands of the lower and middle lungs, and there are fewer upper lungs.
In severe cases, the lungs are full of lesions on the CT image. The ventilation function of the lungs is severely impaired, and the oxygen saturation is significantly reduced. The clinical manifestations are fever, cough, sputum, dyspnea, and multiple organ failure. Shock, coma, and even going to die.